Cdk regulation of cell polarity in yeast 1 Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 Cdks in Saccharomyces cerevisiae
نویسندگان
چکیده
Jian Zou, Helena Friesen , Jennifer Larson, Dongqing Huang , Mike Cox, Kelly Tatchell, and Brenda Andrews * Department of Molecular Genetics Banting & Best Department of Medical Research Terrence Donnelly Centre for Cellular & Biomolecular Research University of Toronto 160 College Street, Toronto, Ontario M5S 3E1 Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 USA
منابع مشابه
Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae.
In the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1,2-Cdc28 and Pcl1,2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, the redundancy of Cdks and cyclins means that identification of relevant Cdk substrates remains a significant challenge. We used array-ba...
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It is generally accepted that progression through the eukaryotic cell cycle is driven by cyclin-dependent kinases (CDKs), which are regulated by interaction with oscillatory expressed proteins called cyclins. CDKs may be separated into 2 categories: essential and non-essential. Understandably, more attention has been focused on essential CDKs because they are shown to control cell cycle progres...
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the establishment and maintenance of cell polarity—that is, the asymmetrical partitioning of cellular materials—is fundamental to stem-cell renewal and development. the budding yeast Saccharomyces cerevisiae is a leading model organism for studying cell polarity. yeast cell polarity is intimately connected to the organization of the actin cytoskeleton, which guides secretion towards the budding...
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Complete activation of most cyclin-dependent protein kinases (CDKs) requires phosphorylation by the CDK-activating kinase (CAK). In the budding yeast, Saccharomyces cerevisiae, the major CAK is a 44-kDa protein kinase known as Cak1. Cak1 is required for the phosphorylation and activation of Cdc28, a major CDK involved in cell cycle control. We addressed the possibility that Cak1 is also require...
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